TY - JOUR
T1 - A novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 86
AU - Cerdeira, Louise
AU - Nakamura-Silva, Rafael
AU - Oliveira-Silva, Mariana
AU - Sano, Elder
AU - Esposito, Fernanda
AU - Fuga, Bruna
AU - Moura, Quézia
AU - Miranda, Carlos Eduardo Saraiva
AU - Wyres, Kelly
AU - Lincopan, Nilton
AU - Pitondo-Silva, André
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piauí, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype, and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil.
AB - Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piauí, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype, and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil.
KW - Clonal Group 86
KW - Klebsiella pneumoniae
KW - ST3994
KW - virulence
U2 - 10.1093/femspd/ftab047
DO - 10.1093/femspd/ftab047
M3 - Article
SN - 2049-632X
VL - 79
JO - Pathogens and Disease
JF - Pathogens and Disease
IS - 8
M1 - ftab047
ER -
