A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies

Simon Abrams; Benjamin Morton; Yasir Alhamdi; Mohmad Alsabani; Zhenxing Cheng; Steven Lane; Ingeborg Welters; Guozheng Wang; Cheng-hock Toh

doi:10.1182/blood-2019-128493

A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies

Simon Abrams, Benjamin Morton, Yasir Alhamdi, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, Ingeborg Welters, Guozheng Wang, Cheng-hock Toh

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Neutrophils are the first line of defence against bacterial infection and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. However, NETs can also cause harm by promoting intravascular coagulation and multi-organ failure (MOF) in animal models. Although increasingly considered as important therapeutic targets, there is currently no robust and specific measure of NETs formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance.

Original language	English
Journal	Blood
DOIs	https://doi.org/10.1182/blood-2019-128493
Publication status	Published - 13 Nov 2019

Access to Document

10.1182/blood-2019-128493

ChtAbrams et al ASH 2019 AbstractFINALAccepted author manuscript, 17 KB

Cite this

@article{3cf0505fe0e241e2923111791e56af66,

title = "A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies",

abstract = "Neutrophils are the first line of defence against bacterial infection and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. However, NETs can also cause harm by promoting intravascular coagulation and multi-organ failure (MOF) in animal models. Although increasingly considered as important therapeutic targets, there is currently no robust and specific measure of NETs formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance.",

author = "Simon Abrams and Benjamin Morton and Yasir Alhamdi and Mohmad Alsabani and Zhenxing Cheng and Steven Lane and Ingeborg Welters and Guozheng Wang and Cheng-hock Toh",

year = "2019",

month = nov,

day = "13",

doi = "10.1182/blood-2019-128493",

language = "English",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies

AU - Abrams, Simon

AU - Morton, Benjamin

AU - Alhamdi, Yasir

AU - Alsabani, Mohmad

AU - Cheng, Zhenxing

AU - Lane, Steven

AU - Welters, Ingeborg

AU - Wang, Guozheng

AU - Toh, Cheng-hock

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Neutrophils are the first line of defence against bacterial infection and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. However, NETs can also cause harm by promoting intravascular coagulation and multi-organ failure (MOF) in animal models. Although increasingly considered as important therapeutic targets, there is currently no robust and specific measure of NETs formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance.

AB - Neutrophils are the first line of defence against bacterial infection and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. However, NETs can also cause harm by promoting intravascular coagulation and multi-organ failure (MOF) in animal models. Although increasingly considered as important therapeutic targets, there is currently no robust and specific measure of NETs formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance.

U2 - 10.1182/blood-2019-128493

DO - 10.1182/blood-2019-128493

M3 - Article

SN - 0006-4971

JO - Blood

JF - Blood

ER -

A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies

Abstract

Access to Document

Fingerprint

Cite this