A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

Noushin Emami; Bo G. Lindberg; Susanna Hua; Sharon R. Hill; Raimondas Mozuraitis; Philipp Lehmann; Göran Birgersson; Anna Karin Borg-Karlson; Rickard Ignell; Ingrid Faye

doi:10.1126/science.aah4563

A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

Noushin Emami, Bo G. Lindberg, Susanna Hua, Sharon R. Hill, Raimondas Mozuraitis, Philipp Lehmann, Göran Birgersson, Anna Karin Borg-Karlson, Rickard Ignell, Ingrid Faye

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.

Original language	English
Pages (from-to)	1076-1080
Number of pages	5
Journal	Science
Volume	355
Issue number	6329
DOIs	https://doi.org/10.1126/science.aah4563
Publication status	Published - 10 Mar 2017
Externally published	Yes

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title = "A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection",

abstract = "Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.",

author = "Noushin Emami and Lindberg, \{Bo G.\} and Susanna Hua and Hill, \{Sharon R.\} and Raimondas Mozuraitis and Philipp Lehmann and G{\"o}ran Birgersson and Borg-Karlson, \{Anna Karin\} and Rickard Ignell and Ingrid Faye",

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T1 - A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

AU - Emami, Noushin

AU - Lindberg, Bo G.

AU - Hua, Susanna

AU - Hill, Sharon R.

AU - Mozuraitis, Raimondas

AU - Lehmann, Philipp

AU - Birgersson, Göran

AU - Borg-Karlson, Anna Karin

AU - Ignell, Rickard

AU - Faye, Ingrid

PY - 2017/3/10

Y1 - 2017/3/10

N2 - Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.

AB - Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.

U2 - 10.1126/science.aah4563

DO - 10.1126/science.aah4563

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VL - 355

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JF - Science

IS - 6329

ER -

A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

Abstract

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