A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries.

Birgitta Gleeson; Cecilia Ferreyra; Kara Palamountain; Shevin Jacob; Naomi Spotswood; Niranjan Kissoon; Yasir Bin Nisar; Felicity Fitzgerald; Sarah Murless-Collins; Uduak Okomo; James H. Cross; Elizabeth Molyneux; Erwan Piriou; Kenechukwu K. Iloh; Santorino Data; David Goldfarb; Alex Stevenson; Rebecca Kirby; Brooke E. Nichols; Benjamin Blumel; Cassandra Kelly-Cirino; Timothy Walsh; Lizel Lloyd; Sara Liaghati-Mobarhan; Ana Belen Ibarz; Joshua Chevalier; Marta Fernandez-Suarez; François Franceschi; Gwenaelle Hamon; Megan Hansen; Shaukat Khan; Noah Mataruse; André Ndayambaje; Seamus O’Brien; Antonio Pedrotta; Vishakha Sharma; Wallace White

doi:10.1136/bmjgh-2024-015862

A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries.

Birgitta Gleeson, Cecilia Ferreyra, Kara Palamountain, Shevin Jacob, Naomi Spotswood, Niranjan Kissoon, Yasir Bin Nisar, Felicity Fitzgerald, Sarah Murless-Collins, Uduak Okomo, James H. Cross, Elizabeth Molyneux, Erwan Piriou, Kenechukwu K. Iloh, Santorino Data, David Goldfarb, Alex Stevenson, Rebecca Kirby, Brooke E. Nichols, Benjamin BlumelCassandra Kelly-Cirino, Timothy Walsh, Lizel Lloyd, Sara Liaghati-Mobarhan, Ana Belen Ibarz, Joshua Chevalier, Marta Fernandez-Suarez, François Franceschi, Gwenaelle Hamon, Megan Hansen, Shaukat Khan, Noah Mataruse, André Ndayambaje, Seamus O’Brien, Antonio Pedrotta, Vishakha Sharma, Wallace White

Clinical Sciences

Research output: Contribution to journal › Comment/debate

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Abstract

Low- and middle-income countries (LMICs) bear the greatest burden of neonatal mortality, with sepsis being a major contributor.

Non-specificity of signs, and the absence of a definitive diagnostic, present a challenge to the identification of sepsis and can lead to underdiagnosis or overdiagnosis, both of which can have harmful consequences.

As early intervention can be life-saving, sepsis protocols, which commonly include empiric therapies, result in the overuse of antibiotics and the development of antimicrobial resistance.

Affordable and accurate diagnostic tests that can detect neonatal sepsis at or near the point of care could contribute to reduced sepsis-related mortality in LMICs and support antimicrobial stewardship.

A screening test to guide referral to hospital from primary care, and an in-hospital test to guide treatment decisions, are high priorities.

Considerable investment will be needed to support the development of these diagnostics.

Original language	English
Article number	e015862
Pages (from-to)	e015862
Journal	BMJ Global Health
Volume	9
Issue number	9
DOIs	https://doi.org/10.1136/bmjgh-2024-015862
Publication status	Published - 10 Sept 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gleeson, B., Ferreyra, C., Palamountain, K., Jacob, S., Spotswood, N., Kissoon, N., Nisar, Y. B., Fitzgerald, F., Murless-Collins, S., Okomo, U., Cross, J. H., Molyneux, E., Piriou, E., Iloh, K. K., Data, S., Goldfarb, D., Stevenson, A., Kirby, R., Nichols, B. E., ... White, W. (2024). A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries. BMJ Global Health, 9(9), e015862. Article e015862. https://doi.org/10.1136/bmjgh-2024-015862

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title = "A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries.",

abstract = "Low- and middle-income countries (LMICs) bear the greatest burden of neonatal mortality, with sepsis being a major contributor.Non-specificity of signs, and the absence of a definitive diagnostic, present a challenge to the identification of sepsis and can lead to underdiagnosis or overdiagnosis, both of which can have harmful consequences.As early intervention can be life-saving, sepsis protocols, which commonly include empiric therapies, result in the overuse of antibiotics and the development of antimicrobial resistance.Affordable and accurate diagnostic tests that can detect neonatal sepsis at or near the point of care could contribute to reduced sepsis-related mortality in LMICs and support antimicrobial stewardship.A screening test to guide referral to hospital from primary care, and an in-hospital test to guide treatment decisions, are high priorities.Considerable investment will be needed to support the development of these diagnostics.",

author = "Birgitta Gleeson and Cecilia Ferreyra and Kara Palamountain and Shevin Jacob and Naomi Spotswood and Niranjan Kissoon and Nisar, {Yasir Bin} and Felicity Fitzgerald and Sarah Murless-Collins and Uduak Okomo and Cross, {James H.} and Elizabeth Molyneux and Erwan Piriou and Iloh, {Kenechukwu K.} and Santorino Data and David Goldfarb and Alex Stevenson and Rebecca Kirby and Nichols, {Brooke E.} and Benjamin Blumel and Cassandra Kelly-Cirino and Timothy Walsh and Lizel Lloyd and Sara Liaghati-Mobarhan and Ibarz, {Ana Belen} and Joshua Chevalier and Marta Fernandez-Suarez and Fran{\c c}ois Franceschi and Gwenaelle Hamon and Megan Hansen and Shaukat Khan and Noah Mataruse and Andr{\'e} Ndayambaje and Seamus O{\textquoteright}Brien and Antonio Pedrotta and Vishakha Sharma and Wallace White",

year = "2024",

month = sep,

day = "10",

doi = "10.1136/bmjgh-2024-015862",

language = "English",

volume = "9",

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journal = "BMJ Global Health",

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Gleeson, B, Ferreyra, C, Palamountain, K, Jacob, S, Spotswood, N, Kissoon, N, Nisar, YB, Fitzgerald, F, Murless-Collins, S, Okomo, U, Cross, JH, Molyneux, E, Piriou, E, Iloh, KK, Data, S, Goldfarb, D, Stevenson, A, Kirby, R, Nichols, BE, Blumel, B, Kelly-Cirino, C, Walsh, T, Lloyd, L, Liaghati-Mobarhan, S, Ibarz, AB, Chevalier, J, Fernandez-Suarez, M, Franceschi, F, Hamon, G, Hansen, M, Khan, S, Mataruse, N, Ndayambaje, A, O’Brien, S, Pedrotta, A, Sharma, V & White, W 2024, 'A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries.', BMJ Global Health, vol. 9, no. 9, e015862, pp. e015862. https://doi.org/10.1136/bmjgh-2024-015862

TY - JOUR

T1 - A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries.

AU - Gleeson, Birgitta

AU - Ferreyra, Cecilia

AU - Palamountain, Kara

AU - Jacob, Shevin

AU - Spotswood, Naomi

AU - Kissoon, Niranjan

AU - Nisar, Yasir Bin

AU - Fitzgerald, Felicity

AU - Murless-Collins, Sarah

AU - Okomo, Uduak

AU - Cross, James H.

AU - Molyneux, Elizabeth

AU - Piriou, Erwan

AU - Iloh, Kenechukwu K.

AU - Data, Santorino

AU - Goldfarb, David

AU - Stevenson, Alex

AU - Kirby, Rebecca

AU - Nichols, Brooke E.

AU - Blumel, Benjamin

AU - Kelly-Cirino, Cassandra

AU - Walsh, Timothy

AU - Lloyd, Lizel

AU - Liaghati-Mobarhan, Sara

AU - Ibarz, Ana Belen

AU - Chevalier, Joshua

AU - Fernandez-Suarez, Marta

AU - Franceschi, François

AU - Hamon, Gwenaelle

AU - Hansen, Megan

AU - Khan, Shaukat

AU - Mataruse, Noah

AU - Ndayambaje, André

AU - O’Brien, Seamus

AU - Pedrotta, Antonio

AU - Sharma, Vishakha

AU - White, Wallace

PY - 2024/9/10

Y1 - 2024/9/10

N2 - Low- and middle-income countries (LMICs) bear the greatest burden of neonatal mortality, with sepsis being a major contributor.Non-specificity of signs, and the absence of a definitive diagnostic, present a challenge to the identification of sepsis and can lead to underdiagnosis or overdiagnosis, both of which can have harmful consequences.As early intervention can be life-saving, sepsis protocols, which commonly include empiric therapies, result in the overuse of antibiotics and the development of antimicrobial resistance.Affordable and accurate diagnostic tests that can detect neonatal sepsis at or near the point of care could contribute to reduced sepsis-related mortality in LMICs and support antimicrobial stewardship.A screening test to guide referral to hospital from primary care, and an in-hospital test to guide treatment decisions, are high priorities.Considerable investment will be needed to support the development of these diagnostics.

AB - Low- and middle-income countries (LMICs) bear the greatest burden of neonatal mortality, with sepsis being a major contributor.Non-specificity of signs, and the absence of a definitive diagnostic, present a challenge to the identification of sepsis and can lead to underdiagnosis or overdiagnosis, both of which can have harmful consequences.As early intervention can be life-saving, sepsis protocols, which commonly include empiric therapies, result in the overuse of antibiotics and the development of antimicrobial resistance.Affordable and accurate diagnostic tests that can detect neonatal sepsis at or near the point of care could contribute to reduced sepsis-related mortality in LMICs and support antimicrobial stewardship.A screening test to guide referral to hospital from primary care, and an in-hospital test to guide treatment decisions, are high priorities.Considerable investment will be needed to support the development of these diagnostics.

U2 - 10.1136/bmjgh-2024-015862

DO - 10.1136/bmjgh-2024-015862

M3 - Comment/debate

SN - 2059-7908

VL - 9

SP - e015862

JO - BMJ Global Health

JF - BMJ Global Health

IS - 9

M1 - e015862

ER -

A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries.

Abstract

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