1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

Jacob E Crawford; Dario Balcazar; Seth Redmond; Noah H. Rose; Henry Youd; Eric Lucas; Rusdiyah  Sudirman Made Ali; Ashwaq Alnazawi; Athanase Badolo; Chun Hong Chen; Luciano V. Cosme; Jennifer  A. Henke; Kim Y. Hung; Susanne  Kluh; Wei-Liang Liu; Kevin Maringer; Ademir J. Martins; María Victoria Micieli1; Evlyn Pless; Aboubacar Sombié; Sinnathamby Noble Surendran; Isra Wahid; Peter A.  Armbruster; David Weetman; Carolyn S. McBride; Andrea Gloria-Soria; Jeffrey R. Powell; Bradley J. White

doi:10.1126/science.ads3732

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

Jacob E Crawford
, Dario Balcazar
, Seth Redmond
, Noah H. Rose
, Henry Youd
, Eric Lucas
, Rusdiyah Sudirman Made Ali
, Ashwaq Alnazawi
, Athanase Badolo
, Chun Hong Chen
, Luciano V. Cosme
, Jennifer A. Henke
, Kim Y. Hung
, Susanne Kluh
, Wei-Liang Liu
, Kevin Maringer
, Ademir J. Martins
, María Victoria Micieli1
, Evlyn Pless
, Aboubacar Sombié

Sinnathamby Noble Surendran, Isra Wahid, Peter A. Armbruster, David Weetman, Carolyn S. McBride, Andrea Gloria-Soria, Jeffrey R. Powell, Bradley J. White

Verily Life Sciences
Yale University
Universidad Nacional de La Plata
The Connecticut Agricultural Experiment Station
Yale School of Public Health
Princeton University
National Research and Innovation Agency Republic of Indonesia
Jazan University
Université Joseph Ki-Zerbo
National Mosquito-Borne Diseases Control Research Center
National Health Research Institutes Taiwan
University of California
Coachella Valley Mosquito and Vector Control District
Greater Los Angeles County Vector Control District
Pirbright Institute
Fundação Oswaldo Cruz
University of Jaffna
Hasanuddin University Medical Research Centre
National Center for Emerging and Zoonotic Infectious Diseases
Georgetown University

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies Ae. aegypti aegypti (Aaa) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that Aaa movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.

Original language	English
Article number	eads3732
Pages (from-to)	eads3732
Number of pages	13
Journal	Science
Volume	389
Issue number	6766
DOIs	https://doi.org/10.1126/science.ads3732
Publication status	Published - 18 Sept 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Themes

Emerging and Re-Emerging Diseases
Vector Control and Resistance Management

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10.1126/science.ads3732Licence: Other

Science accepted version July 2025Accepted author manuscript, 8.19 MBLicence: Other

Cite this

Crawford, J. E., Balcazar, D., Redmond, S., Rose, N. H., Youd, H., Lucas, E., Sudirman Made Ali, R., Alnazawi, A., Badolo, A., Chen, C. H., V. Cosme, L., A. Henke, J., Y. Hung, K., Kluh, S., Liu, W.-L., Maringer, K., Martins, A. J., Micieli1, M. V., Pless, E., ... White, B. J. (2025). 1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk. Science, 389(6766), eads3732. Article eads3732. https://doi.org/10.1126/science.ads3732

@article{bc557c36998c4cc49c319dafb69a447d,

title = "1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk",

abstract = "The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies Ae. aegypti aegypti (Aaa) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that Aaa movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector. ",

author = "Crawford, \{Jacob E\} and Dario Balcazar and Seth Redmond and Rose, \{Noah H.\} and Henry Youd and Eric Lucas and \{Sudirman Made Ali\}, Rusdiyah and Ashwaq Alnazawi and Athanase Badolo and Chen, \{Chun Hong\} and \{V. Cosme\}, Luciano and \{A. Henke\}, Jennifer and \{Y. Hung\}, Kim and Susanne Kluh and Wei-Liang Liu and Kevin Maringer and Martins, \{Ademir J.\} and Micieli1, \{Mar{\'i}a Victoria\} and Evlyn Pless and Aboubacar Sombi{\'e} and Surendran, \{Sinnathamby Noble\} and Isra Wahid and Armbruster, \{Peter A.\} and David Weetman and McBride, \{Carolyn S.\} and Andrea Gloria-Soria and Powell, \{Jeffrey R.\} and White, \{Bradley J.\}",

note = "This is the author{\textquoteright}s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 18 September 2025; DOI: 10.1126/science.ads3732 The version uploaded here has been confirmed by David Weetman as the accepted version and that we are allowed to post it here, despite the labelling. (RK 9/10/2025) ",

year = "2025",

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language = "English",

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Crawford, JE, Balcazar, D, Redmond, S, Rose, NH, Youd, H , Lucas, E, Sudirman Made Ali, R, Alnazawi, A, Badolo, A, Chen, CH, V. Cosme, L, A. Henke, J, Y. Hung, K, Kluh, S, Liu, W-L, Maringer, K, Martins, AJ, Micieli1, MV, Pless, E, Sombié, A, Surendran, SN, Wahid, I, Armbruster, PA, Weetman, D, McBride, CS, Gloria-Soria, A, Powell, JR & White, BJ 2025, '1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk', Science, vol. 389, no. 6766, eads3732, pp. eads3732. https://doi.org/10.1126/science.ads3732

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T1 - 1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

AU - Crawford, Jacob E

AU - Balcazar, Dario

AU - Redmond, Seth

AU - Rose, Noah H.

AU - Youd, Henry

AU - Lucas, Eric

AU - Sudirman Made Ali, Rusdiyah

AU - Alnazawi, Ashwaq

AU - Badolo, Athanase

AU - Chen, Chun Hong

AU - V. Cosme, Luciano

AU - A. Henke, Jennifer

AU - Y. Hung, Kim

AU - Kluh, Susanne

AU - Liu, Wei-Liang

AU - Maringer, Kevin

AU - Martins, Ademir J.

AU - Micieli1, María Victoria

AU - Pless, Evlyn

AU - Sombié, Aboubacar

AU - Surendran, Sinnathamby Noble

AU - Wahid, Isra

AU - Armbruster, Peter A.

AU - Weetman, David

AU - McBride, Carolyn S.

AU - Gloria-Soria, Andrea

AU - Powell, Jeffrey R.

AU - White, Bradley J.

N1 - This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 18 September 2025; DOI: 10.1126/science.ads3732 The version uploaded here has been confirmed by David Weetman as the accepted version and that we are allowed to post it here, despite the labelling. (RK 9/10/2025)

PY - 2025/9/18

Y1 - 2025/9/18

N2 - The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies Ae. aegypti aegypti (Aaa) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that Aaa movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.

AB - The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies Ae. aegypti aegypti (Aaa) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that Aaa movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.

U2 - 10.1126/science.ads3732

DO - 10.1126/science.ads3732

M3 - Article

SN - 0036-8075

VL - 389

SP - eads3732

JO - Science

JF - Science

IS - 6766

M1 - eads3732

ER -

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

Abstract

UN SDGs

Themes

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