Research output per year
Research output per year
Personal profile
Biography
Tom Fletcher is a Professor of Emerging and High Consequence Infectious Diseases, and Director of the Global Health Trials Unit at Liverpool School of Tropical Medicine (LSTM). He is also an honorary Consultant in Infectious Diseases and General Internal Medicine at the Royal Liverpool University Hospital and UK Health Security Agency. After completing undergraduate training at University of Leeds, Tom undertook his general duties in the Defence Medicine Services and then higher specialist training in Liverpool, before retiring from the military in 2024. He was seconded to the department of Pandemic and Epidemic Diseases at HQ World Health Organisation for a year before the 2013-15 Ebola Virus Disease outbreak in West Africa, during which he and colleagues from the World Health Organisation clinical team led a step change in Ebola case management. For his PhD Tom undertook a Wellcome Trust fellowship investigating Crimean-Congo Hemorrhagic Fever in Turkiye. During the COVID-19 pandemic, he returned to HQ World Health Organisation clinical team and was deployed to South Korea before returning to support the UK NHS response. He continues to deploy to filovirus disease outbreaks for the World Health Organisation, most recently in Uganda in 2022 and Rwanda in 2024.
Research interests
Tom's research at LSTM is mainly focussed on high-consequence infectious diseases, where he is the Co-Director of the ACTIVE platform - ACcelerating Therapeutics and dIagnostics in Viral HaEmorrhagic fever. He has active research programmes in Turkiye and West Africa. Tom is a senior investigator within the AGILE trial platform, leading AGILE International and the laboratory pillar. He was a candidate chief investigator on 2 early phase trials of novel therapeutics in COVID-19 in the UK and South Africa. In Crimean-Congo Hemorrhagic Fever he is the Chief Investigator in the UMIT-1 and UMIT-2 therapeutic trials and through his network has developed and evaluated near patient diagnostic platforms. His other research focusses on emerging infections, including in pathogenesis the loss of haemostasis in viral haemorrhagic fevers. He is the chief investigator of the SAND program, a one health grant with the Kingdom of Saudi Arabia developing diagnostic tests for zoonotic infections. He is currently the Chair the World Health Organisation mpox guideline development group.
Teaching
Tom has a large research group in LSTM and supervises 10 PhD students currently. He teaches on the Diploma in Tropical Medicine & Hygiene, the Diploma in Tropical Nursing Masters in Tropical and Infectious Diseases and externally the Military Tropical Medicine and Infectious Diseases.
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Collaborations and top research areas from the last five years
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A Comparison of Clinical and Laboratory Features of Crimean-Congo Hemorrhagic Fever in Children and Adults: A Retrospective Single-Center Cohort Study and Literature Review
Bozkurt, I., Erdeniz, E. H., Riley, M., Şensoy, L., Beeching, N., Aydogdu, S., Leblebicioglu, H., Korukluoglu, G. & Fletcher, T., 1 Feb 2025, In: Vector-Borne and Zoonotic Diseases. 25, 2, p. 81-91 11 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus) -
Adaptive Design for Phase II/III Platform Trial of Lassa Fever Therapeutics
Bourner, J., Vaillant, M., Salam, A. P. A., Jaspard, M., Fritzell, C., Jacob, S., Fletcher, T., Ramharter, M., Ajayi, N., Okogbenin, S., Erameh, C., Grant, D., Samuels, R., Ayodeji, O. O., Sprecher, A., Gonçalves, B. P., Edwards, T. & Olliaro, P., 21 Jan 2025, In: Emerging Infectious Diseases. 31, 2, p. e9-e16Research output: Contribution to journal › Article › peer-review
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Air and surface sampling for clade Ib monkeypox virus in United Kingdom hospitals, 2024 to 2025
Atkinson, B., Gould, S., Nicholls, I., Manzoor, K. N., Smith, J., Hindle, A. J., Tunbridge, A. J., Cole, J., Collini, P., Alonso, A., O'Hara, G., Tuudah, C., Otter, J. A., Hack, B., Taylor, C., Pottage, T., Fletcher, T. & Dunning, J., 15 May 2025, In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 30, 19Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Arboviruses in UK Armed Forces: a review of historical cases and identification of future threats
Kain, M. J. W., Eskell, M., Clark, B., Lambert, C., Weaver, E., Holden, G., A Dermont, M., Beeching, N., Fletcher, T. & Woolley, S., 16 Apr 2025, In: BMJ Military Health. 002987.Research output: Contribution to journal › Article › peer-review
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Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom
ISARIC 4, C Investigators, Ishara-Nshombo, E., Somasundaran, A., Romero-Ramirez, A., Kontogianni, K., Mukadi-Bamuleka, D., Mukoka-Ntumba, M., Muhindo-Milonde, E., Mirimo-Nguee, H., Parkes, J., Hussain, Y., Gould, S., Williams, C. T., Wooding, D., Nkeramahame, J., Watson, M., Hardwick, H. E., Semple, M. G. & Baillie, J. K. & 6 others, , 2 May 2025, In: Emerging Infectious Diseases. 31, 6, p. 1140-1148 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)
Thesis
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Pathogenesis of Crimean-Congo Haemorrhagic Fever (CCHF) - interaction of immune response, viral load and clinical course
Fletcher, T. (Author), Beeching, N. (Supervisor) & Lalloo, D. (Supervisor), 2019Student thesis: Doctoral thesis
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