Personal profile
Biography
Research interests
Simon’s main research interests are in the development and deployment of computational tools to translational tropical medicine. Initially this focused on snake venoms but now includes parasites, vectors, bacteria and viruses. His research is applied and translational – aimed at extracting meaning from biological datasets and solving complex real-world problems, improving predictive accuracy and efficiency, and uncovering hidden meaning and patterns in biological datasets. This involves bioinformatics, but also fundamentals of data transformations, coding, visualisation, specialist hardware and structured scientific logic and their application in biomedical research. Simon is engaged in a number of collaborative projects with other research groups in LSTM and works closely with research groups across the institution to ensure they have access to the best available computational tools and technologies to support their research.
Teaching
Simon contributes to Applied Bioinformatics and other modules throughout the MSc portfolio. He is an experienced educator and trainer and champions technology for all - developing tools and infrastructure to remove barriers to technology uptake and empowering early career researchers to take on their own data challenges.
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Collaborations and top research areas from the last five years
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Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts
Quek, S., Hadermann, A., Wu, Y., De Coninck, L., Hegde, S., Boucher, J. R., Cresswell, J., Foreman, E., Steven, A., LaCourse, J., Ward, S., Wanji, S., Hughes, G., Patterson, I., Wagstaff, S., Turner, J., Parry, R. H., Kohl, A., Heinz, E. & Otabil, K. B. & 3 others, , 4 Sept 2024, In: Nature Microbiology. 9, 10, p. 2488-2505 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus) -
Intraspecific venom variation in the medically important puff adder ( Bitis arietans ): Comparative venom gland transcriptomics, in vitro venom activity and immunological recognition by antivenom
Dawson, C., Bartlett, K., Wilkinson, M., Ainsworth, S., Albulescu, L.-O., Kazandijan, T., Hall, S. R., Westhorpe, A., Clare, R., Wagstaff, S., Modahl, C., Harrison, R. & Casewell, N., 18 Oct 2024, In: PLoS Neglected Tropical Diseases. 18, 10, p. e0012570 e0012570.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus) -
Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture
Othman, B., Zeef, L., Szestak, T., Rchiad, Z., Storm, J., Askonas, C., Satyam, R., Madkhali, A., Haley, M., Wagstaff, S., Couper, K., Pain, A. & Craig, A., 30 Nov 2023, In: PLoS ONE. 18, 11 November, p. e0295053 e0295053.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment
Quek, S., Cook, D. A. N., Wu, Y., Marriott, A., Steven, A., Johnston, K., Ford, L., Archer, J., Hemingway, J., Ward, S., Wagstaff, S., Turner, J. & Taylor, M., 12 Apr 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 15, p. e2120003119 e2120003119.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus) -
Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras
Kazandjian, T., Petras, D., Robinson, S. D., van Thiel, J., Greene, H. W., Arbuckle, K., Barlow, A., Carter, D. A., Wouters, R. M., Whiteley, G., Wagstaff, S., Arias, A. S., Albulescu, L.-O., Plettenberg Laing, A., Hall, C., Heap, A., Penrhyn-Lowe, S., McCabe, C. V., Ainsworth, S. & da Silva, R. R. & 9 others, , 22 Jan 2021, In: Science. 371, 6527, p. 386-390 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile136 Citations (Scopus)
Datasets
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Dataset for the article: Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture
Othman, B. (Creator), Zeef, L. (Creator), Szestak, T. (Creator), Rchiad, Z. (Creator), Storm, J. (Creator), Askonas, C. (Creator), Satyam, R. (Creator), Madkhali, A. (Creator), Haley, M. (Creator), Wagstaff, S. (Creator), Pain, A. (Creator) & Craig, A. (Creator), tbc, 20 Sept 2023
Dataset
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