Personal profile
Biography
Saskia Stenzel obtained her BSc in Biology at the Freie Universität of Berlin in 2018, working on multi-resistant staphylococcus aureus. She progressed onto a master’s focussing on molecular and cell biology including courses for immunology and virology, which sparked an interest in infectious diseases and specifically viruses. In 2019, Saskie started a research internship in Prof. Christine Goffinet’s lab working on HIV-1 latency reversal. Due to the pandemic and the urgent need for research in the field of human pathogenic coronaviruses, she continued with a master’s project on SARS-CoV-2 and the susceptibility to innate immune response factors. After completing her master’s in 2021, she started a PhD in Prof. Goffinet’s group. Currently, Sakia is working as a Research Assistant in the department of Tropical Disease Biology, at Liverpool School of Tropical Medicine.
Research interests
Using complex lung cell models, functional assays and reverse genetics, Saskia's current research focuses on investigating the efficiency and characteristics of SARS-CoV-2 transmission modes: cell-free virus particle transmission and direct cell-to-cell contact transmission. Understanding these modes is crucial for developing effective therapeutic strategies and vaccines, as cell-to-cell transmission may accelerate viral spread and aid in immune evasion, especially in cell-dense respiratory tissues.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Research output
- 5 Article
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A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea
Mottaghinia, S., Stenzel, S., Tsangaras, K., Nikolaidis, N., Laue, M., Müller, K., Hölscher, H., Löber, U., McEwen, G. K., Donnellan, S. C., Rowe, K. C., Aplin, K. P., Goffinet, C. & Greenwood, A. D., 1 Feb 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 6, p. e2220392121 e2220392121.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus) -
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
Mhlekude, B., Postmus, D., Stenzel, S., Weiner, J., Jansen, J., Zapatero-Belinchón, F. J., Olmer, R., Richter, A., Heinze, J., Heinemann, N., Mühlemann, B., Schroeder, S., Jones, T. C., Müller, M. A., Drosten, C., Pich, A., Thiel, V., Martin, U., Niemeyer, D. & Gerold, G. & 2 others, , 25 Sept 2023, In: PLoS Pathogens. 19, 9 September, p. e1011657 e1011657.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
Niemeyer, D., Stenzel, S., Veith, T., Schroeder, S., Friedmann, K., Weege, F., Trimpert, J., Heinze, J., Richter, A., Jansen, J., Emanuel, J., Kazmierski, J., Pott, F., Jeworowski, L. M., Olmer, R., Jaboreck, M. C., Tenner, B., Papies, J., Walper, F. & Schmidt, M. L. & 23 others, , 1 Nov 2022, In: PLoS Biology. 20, 11, e3001871.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Scopus) -
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction
Franz, S., Pott, F., Zillinger, T., Schöler, C., Dapa, S., Fischer, C., Passos, V. A., Stenzel, S., Chen, F., Döhner, K., Hartmann, G., Sodeik, B., Pessler, F., Simmons, G., Drexler, J. F. & Goffinet, C., 1 Jul 2021, In: Life Science Alliance. 4, 7, e202000909.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Staphylococcus aureus uses the bacilliredoxin (BrxAB)/bacillithiol disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections
Linzner, N., Van Loi, V., Fritsch, V. N., Tung, Q. N., Stenzel, S., Wirtz, M., Hell, R., Hamilton, C. J., Tedin, K., Fulde, M. & Antelmann, H., 1 Jan 2019, In: Frontiers in Microbiology. 10, JUN, 1355.Research output: Contribution to journal › Article › peer-review
Open Access39 Citations (Scopus)