Personal profile
Biography
Dr Richard A. Urbanowicz is Senior Lecturer in Antibody Discovery and Immunology at the Liverpool School of Tropical Medicine (LSTM), where he leads a research programme focused on antibody-mediated immunity to viral pathogens. He has over 20 years’ experience spanning immunology and virology, with expertise in monoclonal antibody discovery, viral entry mechanisms, and vaccine-relevant immune responses.
He obtained a B.Sc. in Microbiology and Virology from the University of Warwick, followed by an M.Sc. in Immunology and Allergy and a Ph.D. in Immunology at the University of Nottingham. His doctoral work, conducted under Prof. Lucy Fairclough, investigated the role of cytotoxic immune cells in chronic obstructive pulmonary disease (COPD).
Dr Urbanowicz remained in Nottingham for postdoctoral training with Prof. Jonathan Ball, where he contributed to a series of high-impact studies on viral immunology. His work included the characterisation of monoclonal antibodies for clinical trials targeting Hepatitis C virus (HCV), isolation of novel human antibodies, and development of widely used viral pseudotype systems. He also played a key role in research demonstrating how genetic changes in Ebola virus during the 2014 West African outbreak enhanced viral infectivity in human cells.
In 2021, he established his independent research group at the University of Liverpool before moving to LSTM in 2025. He has published over 55 peer-reviewed articles (H-index 30) and has secured ~£4M in research funding as PI or Co-I . In addition to his research, he contributes extensively to teaching, postgraduate supervision, and academic leadership.
He serves as an Associate Editor for Virulence, is a member of The Pandemic Institute’s Internal Scientific Advisory Panel, and regularly reviews for major journals and international funding bodies. He is also a Fellow of the Higher Education Academy and a member of multiple professional societies, including the British Society for Immunology and the Microbiology Society.
Research interests
The Urbanowicz laboratory focuses on understanding how antibodies recognise viral pathogens and how they engage the wider immune system to mediate protection and clearance. The group integrates virology, immunology, and molecular engineering to define the features of effective antibody responses and translate these into improved therapeutics and vaccines.
A central theme of the research is the dissection of antibody function beyond neutralisation, including Fc-mediated effector mechanisms such as phagocytosis, complement activation, and cellular cytotoxicity. The lab applies systems serology approaches to identify correlates of protective immunity and to understand how antibody quality, rather than simply quantity, determines clinical outcomes.
The group has established platforms for monoclonal antibody discovery and characterisation across multiple viral families, including flaviviruses, coronaviruses, arenaviruses, and filoviruses. This includes the use of advanced pseudotype systems and diverse glycoprotein panels to interrogate viral entry and antibody breadth.
Current projects span:
Development of broadly protective antibody responses against emerging and zoonotic viruses
Engineering of antibody function to enhance antiviral efficacy
Investigation of viral evolution and its impact on antibody recognition and infectivity
Translation of antibody platforms into diagnostics and therapeutic candidates
The overarching aim is to harness the full functional capacity of antibodies to inform next-generation vaccines, biologics, and rapid response strategies against emerging infectious diseases.
Teaching
lectures on several modules of the MSc Tropical Disease Biology as well as professional diplomas. With his lab team he regularly co-supervises MSc and MRes project students.
Related documents
Education/Academic qualification
PhD, Ph.D IN IMMUNOLOGY - Peripheral Cytotoxic Cells in Chronic Obstructive Pulmonary Disease, University of Nottingham
Award Date: 1 Jun 2008
Master, MSC IN IMMUNOLOGY AND ALLERGY, University of Nottingham
Award Date: 1 Sept 2004
Bachelor, BSC(INT) (HONOURS) IN MICROBIOLOGY AND VIROLOGY, University of Warwick
Award Date: 1 Jul 2003
Themes
- Innovation to Impact: Therapeutics, Diagnostics, Vaccines
- Malaria and Neglected Tropical Diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
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Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent
Mimms, J. L., Sinnis-Bourozikas, A., Felbinger, N. R., Frumento, N., Paul, H. T., Patel, A. H., Keck, Z., Foung, S. K. H., Law, M., Urbanowicz, R. A., Tarr, A. W., Ball, J. K., Pierce, B. G. & Bailey, J. R., 13 Jan 2026, In: Journal of General Virology. 107, 1, 002201.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Molecular pathogenesis—Part B
Ugwu, C., Cantoni, D., Neto, M. M., Urbanowicz, R. A., Wright, E., Scott, S. & Temperton, N., 1 Jan 2025, Viral Hemorrhagic Fevers: Epidemiology, Pathogenesis, Management, and Preparedness. Elsevier, p. 273-299 27 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex
Duncan, J. D., Pathak, M., King, B. J., Bamber, H., Radford, P., Dey, J., Richardson, C., Astbury, S., McClure, P., Ball, J. K., Urbanowicz, R. A. & Tarr, A. W., 6 Jun 2025, In: Journal of General Virology. 106, 6, 002120.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Phlorotannin-Rich Ascophyllum nodosum Seaweed Extract Inhibits Influenza Infection
Mega, D. F., Sharma, P., Kipar, A., Hetzel, U., Bramwell, C., Merritt, A., Wright, S., Plummer, C., Urbanowicz, R. A. & Stewart, J. P., 15 Dec 2024, In: Viruses. 16, 12, 1919.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone
Kundu, J., Le, H. T., Logan, M., Hockman, D., Landi, A., Crawford, K., Wininger, M., Johnson, J., Kundu, J. K., Tiffney, E. A., Urbanowicz, R. A., Ball, J., Bailey, J. R., Bukh, J., Law, M., Foung, S., Tyrrell, D. L., Houghton, M. & Law, J. L., 1 Dec 2024, In: Journal of Hepatology. 81, 6, p. 941-948 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)