Personal profile
Biography
Dr Paine graduated in Genetics from Wits University, Johannesburg in 1983. In 1990 he obtained his PhD for research on the molecular biology of viper venoms from Liverpool School of Tropical Medicine (LSTM). In 1993 he moved to the University of Dundee Biomedical Research Centre to work on molecular aspects of human drug metabolising enzymes. In 2006 he returned to LSTM to investigate the chemical detoxification mechanisms of insects and identify and characterise the key enzymes associated with insecticide resistance.
Research interests
Dr Paine heads the Enzyme Characterisation Group whose research is primarily aimed at understanding the molecular mechanisms of insecticide resistance and developing tools to accelerate the development of new active ingredients for vector control. This involves the use of a wide range of biochemical, molecular and analytical techniques and collaborations across academia and industry.
Teaching
Dr Paine teaches aspects of vector biology, insecticide resistance and vector control for undergraduate, MSc, Diploma in Tropical Medicine and Hygiene and Diploma in Tropical Nursing modules.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Susceptibility of Anopheles stephensi SDA500 strain to common insecticides and efficacy of glazed tile bioassay for resistance characterization
Matera, M., Nolden, M., Horstmann, S., Nimmo, D., Paine, M. J. I. & Weetman, D., 5 Jan 2026, In: Current Research in Parasitology and Vector-Borne Diseases. 9, 100347.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Aedes aegypti control in breeding sites through an insecticidal coating with dual effect: Laboratory trials and safety assessment
Cárdenas, R., Cabrera, O. L., Carrillo, M. A., Pineda, A., Ahumada, M. L., Yañez, Y., Ismail, H. M., Paine, M., Rivera, T. & Kroeger, A., 1 Jun 2025, In: Medical and Veterinary Entomology. 39, 2, p. 252-265 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae
Francis, S., Irvine, W., Mackenzie-Impoinvil, L., Vizcaino, L., Poupardin, R., Lenhart, A., Paine, M. & Delgoda, R., 22 Jan 2025, In: Malaria Journal. 24, 1, 25.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
Impact of Vgsc-1014 mutations on the feeding pattern of Phlebotomus argentipes
Gomes, B., Ghosh, D., Chowdhury, R., Huda, M. M., Alim, A., Paine, M., Mondal, D. & Weetman, D., 28 May 2025, In: PLoS ONE. 20, 5 May, e0323802.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii
Muhammad, A., Ibrahim, S. S., Ismail, H. M., Irving, H., Paine, M. J. I. & Wondji, C. S., 7 Nov 2025, In: BMC Genomics. 26, 1, 1018.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Profiles
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Person: PhD, Not an academic contract