Personal profile
Biography
Laura-Oana Albulescu is a Senior Research Associate in the Centre for Snakebite Research and Interventions at Liverpool School of Tropical Medicine (LSTM). She has more than 20 years of experience in biochemistry and molecular biology. Laura-Oana received a BSc in Biochemistry from the University of Bucharest, followed by a doctoral degree in Molecular Biology and Genetics from Cornell University. During her PhD she focused on molecular tools to investigate gene expression regulation and identify links between pre-mRNA splicing, transcription and chromatin remodelling. She then moved to her first postdoctoral position at the University of Oxford where she studied neurodegenerative diseases involving trinucleotide expansions. In 2017 Laura-Oana joined the venom research unit (now the Centre for Snakebite Research and Interventions) at LSTM, where her focus shifted to developing novel therapies for snakebite envenoming. She is mainly interested in the development of novel oral drugs which can be administered immediately after a bite and neutralise a variety of snake venoms – from repurposed drugs to novel molecules developed specifically for snakebite. For the past four years she has been involved in co-managing a programme in drug discovery with collaborators from the University of Liverpool aimed at developing novel inhibitors for enzymatic snake venom toxins. She is also a member of the Biological Safety Committee.
Research interests
Teaching
Laura-Oana supervises and train master’s students at LSTM, guiding their laboratory research and experimental planning.
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Computational Strategies for Broad Spectrum Venom Phospholipase A2 Inhibitors
Poole, D. A., Albulescu, L.-O., Kool, J., Casewell, N. & Geerke, D. P., 22 Apr 2025, (E-pub ahead of print) In: Journal of Chemical Information and Modeling. 65, 9, p. 4593-4601 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults.
Abouyannis, M., Nyambura, Y. K., Ngome, S., Riako, D., Musyoki, J., Muiruri, C., Orindi, B., Else, L., Amara, A., Dickinson, L., Clare, R., Albulescu, L.-O., Westhorpe, A., Kool, J., Adetifa, I., Ndungu, F. M., FitzGerald, R., Khoo, S., Lalloo, D. & Casewell, N. & 1 others, , 27 Feb 2025, In: eBioMedicine. 113, p. e105600 105600.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib
Bartlett, K., Hall, S. R., Rasmussen, S. A., Crittenden, E., Dawson, C., Albulescu, L.-O., Laprade, W., Harrison, R., Saviola, A. J., Modahl, C., Jenkins, T. P., Wilkinson, M., Gutiérrez, J. M. & Casewell, N., 30 Apr 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 19, p. e2315597121 e2315597121.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus) -
Intraspecific venom variation in the medically important puff adder ( Bitis arietans ): Comparative venom gland transcriptomics, in vitro venom activity and immunological recognition by antivenom
Dawson, C., Bartlett, K., Wilkinson, M., Ainsworth, S., Albulescu, L.-O., Kazandijan, T., Hall, S. R., Westhorpe, A., Clare, R., Wagstaff, S., Modahl, C., Harrison, R. & Casewell, N., 18 Oct 2024, In: PLoS Neglected Tropical Diseases. 18, 10, p. e0012570 e0012570.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus) -
Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming
Du, T. Y., Hall, S. R., Chung, F., Kurdyukov, S., Crittenden, E., Patel, K., Dawson, C., Westhorpe, A., Bartlett, K., Rasmussen, S. A., Moreno, C. L., Denes, C. E., Albulescu, L.-O., Marriott, A., Mackay, J. P., Wilkinson, M., Gutiérrez, J. M., Casewell, N. & Neely, G. G., 17 Jul 2024, In: Science Translational Medicine. 16, 756, eadk4802.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)