Personal profile

Biography

Laura-Oana Albulescu is a Senior Research Associate in the Centre for Snakebite Research and Interventions at Liverpool School of Tropical Medicine (LSTM). She has more than 20 years of experience in biochemistry and molecular biology. Laura-Oana received a BSc in Biochemistry from the University of Bucharest, followed by a doctoral degree in Molecular Biology and Genetics from Cornell University. During her PhD she focused on molecular tools to investigate gene expression regulation and identify links between pre-mRNA splicing, transcription and chromatin remodelling. She then moved to her first postdoctoral position at the University of Oxford where she studied neurodegenerative diseases involving trinucleotide expansions. In 2017 Laura-Oana joined the venom research unit (now the Centre for Snakebite Research and Interventions) at LSTM, where her focus shifted to developing novel therapies for snakebite envenoming. She is mainly interested in the development of novel oral drugs which can be administered immediately after a bite and neutralise a variety of snake venoms – from repurposed drugs to novel molecules developed specifically for snakebite. For the past four years she has been involved in co-managing a programme in drug discovery with collaborators from the University of Liverpool aimed at developing novel inhibitors for enzymatic snake venom toxins. She is also a member of the Biological Safety Committee.

Research interests

Laura-Oana’s main focus is on the development of small molecule inhibitors against classes of snake venom toxins – from drug discovery/repurposing all the way into clinical trials. These oral drugs could be taken in the field immediately after a bite, thus improving patient outcomes and buying the victim time to access a healthcare facility. She has concentrated on the main pathology inducing enzymatic toxins such as metalloproteinases and phospholipases, with the aim to broadly neutralise these across viper venoms. She envisions that an oral drug cocktail targeting a combination of these toxin classes will considerably reduce mortality and morbidity following snakebite in remote rural areas without access to or delays in receiving antivenom. Laura-Oana has worked on repurposing metalloproteinases inhibitors from basic in vitro testing into preclinical models and now into an upcoming Phase II clinical trial with partners in Brazil and Ghana. In addition, she is also part of a team testing combinations of novel inhibitors generated by partners the University of Liverpool as part of a Medical Research Council Impact Acceleration Grant.
A second arm of her research focuses on recombinant mimics of the nicotinic acetylcholine receptor which can be used as decoys to bind venom neurotoxins and prevent paralysis. Through an ongoing collaboration with partners at the Universities of Leuven and Amsterdam the team are looking to develop decoy molecules with the ability to capture both short and long-chain neurotoxins from elapid venoms.

Teaching

Laura-Oana supervises and train master’s students at LSTM, guiding their laboratory research and experimental planning.

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