Personal profile
Biography
Research interests
Kelly’s research interests are focused on neglected tropical diseases, in particular lymphatic filariasis and onchocerciasis. The parasites that cause these diseases contain bacteria, wolbachia, which are essential for the biology of the parasites and can be targeted with drugs. She is interested in understanding the biology of these bacteria and their relationships with their host cells. Kelly has been using drug screening data to identify experimental tools that can be used to explore these areas.
Teaching
Kelly is Deputy Director of Studies for the MSc Tropical Disease Biology programme and leads several professional short courses in diagnostic parasitology. She is currently the Module Organiser for Topics in Global Health, a module run by LSTM in collaboration with the University of Liverpool, and co-leads on the MSc module Methods in Tropical Disease Research. Kelly also teaches in teach on the Molecular and Cellular Biology of Pathogens and Vectors module and is a regular demonstrator on the Diploma in Tropical Medicine and Hygiene programme. From the 2026-2027 academic year, Kelly will be leading the BSc Global Infectious Disease programme in partnership with Edge Hill University.
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Collaborations and top research areas from the last five years
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Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.
Hoffmann, G., Lukarska, M., Clare, R., Masters, E., Johnston, K., Ford, L., Turner, J., Ward, S. A., Taylor, M., Jensen, M. R. & Palencia, A., 10 Jul 2024, In: Science advances. 10, 28, p. eado1453 ado1453.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment
Quek, S., Cook, D. A. N., Wu, Y., Marriott, A., Steven, A., Johnston, K., Ford, L., Archer, J., Hemingway, J., Ward, S., Wagstaff, S., Turner, J. & Taylor, M., 12 Apr 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 15, p. e2120003119 e2120003119.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus) -
Anti-Wolbachia drugs for filariasis
Johnston, K., Hong, W. D., Turner, J., O'Neill, P. M., Ward, S. & Taylor, M., 1 Dec 2021, In: Trends In Parasitology. 37, 12, p. 1068-1081 14 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile36 Citations (Scopus) -
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis
McGillan, P., Berry, N. G., Nixon, G. L., Leung, S. C., Webborn, P. J. H., Wenlock, M. C., Kavanagh, S., Cassidy, A., Clare, R., Cook, D. A., Johnston, K., Ford, L., Ward, S., Taylor, M., Hong, W. D. & O'Neill, P. M., 9 Sept 2021, In: ACS Medicinal Chemistry Letters. 12, 9, p. 1421-1426 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis.
David Hong, W., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K., Clare, R., Cassidy, A., Cook, D. A. N., Siu, A., Shiotani, M., Webborn, P. J. H., Kavanagh, S., Aljayyoussi, G., Murphy, E., Steven, A., Archer, J., Struever, D., Frohberger, S. J., Ehrens, A. & Hübner, M. P. & 14 others, , 22 Jan 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1414-1419 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)