Personal profile
Biography
Kayla Barnes is a genomics researcher based at the Malawi-Liverpool Wellcome Trust. Kayla’s lab focuses on two programs that bookend the dynamics of health in low-income countries. These include tracking viral pathogens and vaccines using wastewater and other surveillance tools and understanding, at the omics cell level, why vaccines underperform in low-income countries. Kayla has helped establish pathogen and single cell sequencing in Malawi.
Research interests
Kayla's research interests include genetics, genomics, immunology, single cell, virology, surveillance, diagnostics, immunity, sequencing, single cell transcriptomics.
Teaching
Kayla offers sequencing and single cell workshops.
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Collaborations and top research areas from the last five years
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Cost-effectiveness of wastewater-based environmental surveillance for SARS-CoV-2 in Blantyre, Malawi and Kathmandu, Nepal: A model-based study
Mvundura, M., Ngwira, L. G. C., Shrestha, K. B., Tuladhar, R., Gauld, J., Kerr, C., Barnes, K., Anscombe, C., Sharma, B. & Feasey, N., 24 Apr 2025, In: PLOS Global Public Health. 5, 4 April, p. e0004439 e0004439.Research output: Contribution to journal › Article › peer-review
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Maternal-infant rotavirus-specific antibody kinetics to inform timing of vaccine boosting in Malawi: An observational study
Mandolo, J., Mulira, L., Moyo, M., Mvula, M., Mtonga, F., Henrion, M. Y. R., Wotcheni, W., Cunliffe, N. A., Barnes, K. G., Jambo, K. C. & Jere, K. C., 12 Sept 2025, In: PLoS Medicine. 22, 9, e1004734.Research output: Contribution to journal › Article › peer-review
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Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Kotliar, D., Raju, S., Tabrizi, S., Odia, I., Goba, A., Momoh, M., Sandi, J. D., Nair, P., Phelan, E., Tariyal, R., Eromon, P. E., Mehta, S., Robles-Sikisaka, R., Siddle, K. J., Stremlau, M., Jalloh, S., Gire, S. K., Winnicki, S., Chak, B. & Schaffner, S. F. & 45 others, , 7 Feb 2024, In: Nature Microbiology. 9, 3, p. 751-762 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus) -
Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
Nyirenda, J., Hardy, O. M., Silva Filho, J. D., Herder, V., Attipa, C., Ndovi, C., Siwombo, M., Namalima, T. R., Suwedi-Kapesa, L., Ilia, G., Nyasulu, W., Ngulube, T., Nyirenda, D., Mvaya, L., Phiri, J., Chasweka, D., Eneya, C., Makwinja, C., Phiri, C. & Ziwoya, F. & 27 others, , 20 Nov 2024, (E-pub ahead of print) In: Nature Medicine. 30, 12, p. 3765-3777 13 p., 13850.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
Wastewater-based epidemiology as a public health resource in low- and middle-income settings
Hamilton, K. A., Wade, M. J., Barnes, K., Street, R. A. & Paterson, S., 15 Jun 2024, In: Environmental Pollution. 351, 124045.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus)
Datasets
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Dataset for the article: Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques
Santus, L. (Creator), Sopena-Rios, M. (Creator), García-Pérez, R. (Creator), Lin, A. E. (Creator), Adams, G. C. (Creator), Barnes, K. (Creator), Siddle, K. J. (Creator), Wohl, S. (Creator), Reverter, F. (Creator), Rinn, J. L. (Creator), Bennett, R. S. (Creator), Hensley, L. E. (Creator), Sabeti, P. C. (Creator) & Melé, M. (Creator), tbc, 3 May 2023
Dataset