Personal profile
Biography
Josh Hamilton is a Senior Research Assistant at the Liverpool Vaccine Group, part of the Liverpool School of Tropical Medicine (LSTM), where he works on controlled human infection models for streptococcus pneumoniae, SARS-CoV-2, and respiratory syncytial virus. He is also a PhD student researching nitric oxide-based therapies for respiratory infections. Josh’s’ research focuses on the antimicrobial properties of nitric oxide-releasing macromolecules, and their effects on the immune system.
He graduated with a first-class MPharmacol (Hons) in Pharmacology from the University of Bath. As part of his master’s project, Josh worked at Boehringer Ingelheim, investigating small molecule inhibitors of endoplasmic reticulum stress as potential treatments for pulmonary fibrosis. Since joining LSTM, he has contributed to clinical trials and developed in vitro organoid infection models to study host-pathogen interactions. Josh has experience in processing biological samples, immunophenotyping, and microbiological and virology assays.
In addition to his research, Josh participates in public outreach to support clinical trial recruitment. He has received several awards, including the Society for Mucosal Immunology Technique Sharing Grant and the British Pharmacological Society Schacter Award.
Research interests
Josh’s main research interests are nitric oxide-based therapies, including investigating antimicrobial and immunomodulatory effects of nitric oxide. Mucosal immunity and trained immunity, including understanding how prior exposures shape immune responses at barrier sites. Host-pathogen interactions, including exploring bacterial and viral interactions with the respiratory epithelium. Pulmonary fibrosis, including epithelial cell and fibroblast interactions in chronic lung diseases. Development of in vitro fibrosis models to study mechanisms and potential therapies.
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Research output
- 4 Article
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RSV and rhinovirus increase pneumococcal carriage acquisition and density, whereas nasal inflammation is associated with bacterial shedding.
Mitsi, E., Nikolaou, E., Goncalves, A., Blizard, A., Hill, H., Farrar, M., Hyder-Wright, A., Akeju, O., Hamilton, J., Howard, A., Elterish, F., Solorzano, C., Robinson, R., Reine Gutierrez, J., Collins, A., Gordon, S., Moxon, R. E., Weiser, J. N., Bogaert, D. & Ferreira, D., 17 Aug 2024, In: Cell Host and Microbe. 32, 9, p. 1608-1620.e4Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus) -
Participant perceptions and experiences of a novel community-based respiratory longitudinal sampling method in Liverpool, UK: A mixed methods feasibility study
German, E., Nabwera, H., Robinson, R., Shiham, F., Liatsikos, K., Parry, C., McNamara, C., Kattera, S., Carter, K., Howard, A., Pojar, S., Hamilton, J., Matope, A., Read, J. M., Allen, S., Hill, H., Hawcutt, D. B., Urban, B., Collins, A. & Ferreira, D. & 1 others, , 9 Nov 2023, In: PLoS ONE. 18, 11 November, p. e0294133 e0294133.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus) -
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
Mitsi, E., Diniz, M. O., Reine Gutierrez, J., Collins, A., Robinson, R., Hyder-Wright, A., Farrar, M., Liatsikos, K., Hamilton, J., Onyema, O., Urban, B., Solórzano, C., Belij-Rammerstorfer, S., Sheehan, E., Lambe, T., Draper, S. J., Weiskopf, D., Sette, A., Maini, M. K. & Ferreira, D., 26 Oct 2023, In: Nature Communications. 14, 1, p. e6815 6815.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus) -
Human Infection Challenge with Serotype 3 Pneumococcus
Robinson, R., Mitsi, E., Nikolaou, E., Pojar, S., Chen, T., Reine Gutierrez, J., Nyazika, T., Court, J., Davies, K., Farrar, M., Gonzalez-Dias, P., Hamilton, J., Hill, H., Hitchins, L., Howard, A., Hyder-Wright, A., Lesosky, M., Liatsikos, K., Matope, A. & McLenaghan, D. & 14 others, , 8 Jul 2022, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine. 206, 11, p. 1379-1392 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)