Personal profile
Biography
Joseph Turner researches the immunobiology and chemotherapy of helminth neglected tropical diseases. A major goal of his research is the clinical translation of new therapeutics and diagnostics for filarial neglected tropical diseases which are prioritised for global elimination. He originally trained in Medical Microbiology at Newcastle University. After deciding to specialise in parasitology, Joseph attained an MSc in Molecular Parasitology & Vector Biology from Manchester University in 1999. He gained a PhD in Parasite Immunology from Nottingham University in 2004 in the lab of Professor Jan Bradley, with collaborative field work based at Institute Pasteur, Yaounde, Cameroon, where he established, for the first time, the immune-epidemiological association between type-2 cytokines and age-related immunity to human gastro-intestinal nematodes. From 2003-2007 Joseph was a member of Professor Mark Taylor’s research group at Liverpool School of Tropical Medicine (LSTM) that demonstrated drug targeting of wolbachia as a curative treatment for onchocerciasis and lymphatic filariasis via clinical studies conducted in Cameroon, Ghana and Tanzania. In related lab studies, he defined the molecular basis for wolbachia-mediated inflammation. In 2007 Joseph moved to The Centre for Immunology and Infection at the University of York with Dr Adrian Mountford and gained a Wellcome Trust Departmental Fellowship in 2009 to investigate the host-parasite interactions of experimental schistosome transmission. Joseph was appointed Lecturer in Parasitology at LSTM within the then Molecular and Biochemical Parasitology Group in 2010 and progressed to Professor of Infection Biology in 2022. He currently leads the Department of Tropical Disease Biology.
Research interests
Teaching
Joseph lectures on several modules of the MSc Tropical Disease Biology as well as professional diplomas. With his lab team he regularly co-supervises MSc and MRes project students.
Themes
- Malaria and Neglected Tropical Diseases
- Innovation to Impact: Therapeutics, Diagnostics, Vaccines
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Autophagy is essential for anti-Wolbachia drug efficacy in Brugia malayi and insect cells
Yousef, A., Masters, E. K. G., Wu, Y., Hong, W. D., O’Neill, P. M., Turner, J. D., Ward, S. A. & Taylor, M. J., 16 Mar 2026, In: Frontiers in Microbiology. 17, 1771755.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐ Wolbachia Candidate Macrofilaricide
Devereux, G., Bula, M., Tripp, K., Fitzgerald, R., Eraut, N., Alam, M. S., Moriyama, T., Shinkyo, R., Walker, L., Wang, D., Gusovsky, F., van der Velde, J., Turner, J., Hong, W. D., O'Neill, P. M., Taylor, M. & Ward, S., 24 Jun 2024, In: Clinical Pharmacology in Drug Development. 13, 9, p. 1071-1081 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis
Hegde, S., Marriott, A., Pionnier, N., Steven, A., Bulman, C., Gunderson, E., Vogel, I., Koschel, M., Ehrens, A., Lustigman, S., Voronin, D., Tricoche, N., Hoerauf, A., Hübner, M. P., Sakanari, J., Aljayyoussi, G., Gusovsky, F., Dagley, J., Hong, D. W. & O'Neill, P. & 3 others, , 1 Feb 2024, In: Frontiers in Microbiology. 15, p. 1346068 1346068.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus) -
Current status of immunodeficient mouse models as substitutes to reduce cat and dog use in heartworm preclinical research
Dagley, J., DiCosty, U., Fricks, C., Mansour, A., McCall, S., McCall, J. W., Taylor, M. & Turner, J., 11 Sept 2024, In: F1000Research. 13, 484.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts
Quek, S., Hadermann, A., Wu, Y., De Coninck, L., Hegde, S., Boucher, J. R., Cresswell, J., Foreman, E., Steven, A., LaCourse, J., Ward, S., Wanji, S., Hughes, G., Patterson, I., Wagstaff, S., Turner, J., Parry, R. H., Kohl, A., Heinz, E. & Otabil, K. B. & 3 others, , 4 Sept 2024, In: Nature Microbiology. 9, 10, p. 2488-2505 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)
Datasets
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Dataset for the article: Dirofilariasis mouse models for heartworm preclinical research
Marriott, A. (Creator), Dagley, J. (Creator), Hegde, S. (Creator), Steven, A. (Creator), Fricks, C. (Creator), DiCosty, U. (Creator), Mansour, A. (Creator), Campbell, E. J. (Creator), Wilson, C. M. (Creator), Gusovsky, F. (Creator), Ward, S. (Creator), Hong, W. D. (Creator), O'Neill, P. (Creator), Moorhead, A. (Creator), McCall, S. (Creator), McCall, J. W. (Creator), Taylor, M. (Creator) & Turner, J. (Creator), tbc, 22 Jun 2023
Dataset
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Dataset for 'Current status of immunodeficient mouse models as substitutes to reduce cat and dog use in heartworm preclinical research'
Dagley, J. (Creator), Taylor, M. (Creator) & Turner, J. (Creator), tbc, 23 Apr 2024
DOI: 10.6084/m9.figshare.25250101.v1
Dataset