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Biography

Joseph Turner researches the immunobiology and chemotherapy of helminth neglected tropical diseases. A major goal of his research is the clinical translation of new therapeutics and diagnostics for filarial neglected tropical diseases which are prioritised for global elimination. He originally trained in Medical Microbiology at Newcastle University. After deciding to specialise in parasitology, Joseph attained an MSc in Molecular Parasitology & Vector Biology from Manchester University in 1999. He gained a PhD in Parasite Immunology from Nottingham University in 2004 in the lab of Professor Jan Bradley, with collaborative field work based at Institute Pasteur, Yaounde, Cameroon, where he established, for the first time, the immune-epidemiological association between type-2 cytokines and age-related immunity to human gastro-intestinal nematodes. From 2003-2007 Joseph was a member of Professor Mark Taylor’s research group at Liverpool School of Tropical Medicine (LSTM) that demonstrated drug targeting of wolbachia as a curative treatment for onchocerciasis and lymphatic filariasis via clinical studies conducted in Cameroon, Ghana and Tanzania. In related lab studies, he defined the molecular basis for wolbachia-mediated inflammation. In 2007 Joseph moved to The Centre for Immunology and Infection at the University of York with Dr Adrian Mountford and gained a Wellcome Trust Departmental Fellowship in 2009 to investigate the host-parasite interactions of experimental schistosome transmission. Joseph was appointed Lecturer in Parasitology at LSTM within the then Molecular and Biochemical Parasitology Group in 2010 and progressed to Professor of Infection Biology in 2022. He currently leads the Department of Tropical Disease Biology.

Research interests

Joseph’s lab researches the spectrum of immunological responses that dictate major outcomes of human parasitism by tissue-dwelling helminth neglected tropical diseases: limited, short-term parasitism, chronic parasitism without overt disease and parasitism invoking severe inflammatory morbidity. Understanding the cellular and molecular interface between the human immune system and helminth parasites is key to the rational design of novel drugs, immunotherapies and vaccines enabling more effective and safer treatments for both infection and inflammation-related morbidity. His group are applying research models of helminth neglected tropical diseases considered priority global health problems (namely, filariasis and schistosomiasis), as well as immune-epidemiological surveys of parasitised human populations, to determine cellular and molecular mechanisms of host immunopathology at tissue sites of parasitological assault.
His lab supports drug discovery and development programmes for novel curative drugs and diagnostics to eliminate human filariasis and treat veterinary filarial infections. They have expertise in taking lead therapies into clinical trials to test curative efficacy against the filarial neglected tropical diseases, lymphatic filariasis and onchocerciasis. Two new anti-wolbachia clinical candidates: the macrolide derivative, ABBV-4083 (in partnership with AbbVie and Drugs for neglected Diseases initiative) and the first-in-class azaquinazoline, AWZ1066 (in partnership with Eisai Inc and University of Liverpool) have progressed into Phase I and Phase II clinical trials. Currently they are focussing on the clinical translation of repurposed antibiotics as short-course anti-wolbachia based cures for onchocerciasis. Through an Medical Research Council Programme Grant the group are also currently investigating the potential of targeting inflammatory pathways with affordable inflammatory drugs as anti-morbidity adjunctive therapeutics for lymphatic filariasis lymphoedema and post-microfilaricide treatment adverse reactions.

Teaching

Joseph lectures on several modules of the MSc Tropical Disease Biology as well as professional diplomas. With his lab team he regularly co-supervises MSc and MRes project students.

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