Personal profile
Biography
Dr. Hanafy Mahmoud Ismail is a Lecturer in Vector Biology at Liverpool School of Tropical Medicine (LSTM) and leads the Chemical Biology Group. He obtained his BSc and MSc in Pesticide Chemistry and Toxicology from Alexandria University, Egypt. In 2007, he joined LSTM to focus on molecular aspects of drug and insecticide resistance.
Research interests
Dr. Ismail’s research is dedicated to understanding and tackling the global challenge of insecticide resistance across disease vectors, with a focus on safeguarding the long-term efficacy of control interventions. His work spans the interface of chemical biology, entomology, and pharmacology, leveraging advanced tools such as absorption, distribution, metabolism, and excretion profiling, proteomics, and genetic analysis to uncover resistance mechanisms and predict their impact on product performance. A central aim of his research is to understand how existing resistance mechanism in circulation influence the effectiveness and durability of new insecticides, formulations, and delivery systems-insights that are critical for guiding proactive resistance management and product innovation. By integrating mechanistic understanding with translational application, Dr. Ismail's lab mission supports the development of next-generation vector control strategies that are both sustainable and adaptive to emerging resistance threats.
Teaching
Dr. Ismail provides research-led postgraduate teaching and supervision across pesticide chemistry and toxicology, analytical and organic chemistry, protein chemistry, vector biology, and insecticide resistance. His teaching at LSTM is firmly grounded in real-world public health challenges and is strengthened by active collaboration with academic and industry partners.
He contributes to the MSc modules TROP722 Vector Population Biology and Control, TROP715 Applied Bioinformatics, and TROP733 Research Project: Tropical Disease Biology, where he also serves as Module Convenor and Co-Lead.
Dr. Ismail welcomes enquiries from prospective postgraduate students interested in interdisciplinary research at the interface of pesticide chemistry, insecticide resistance, applied chemical biology, and vector control. He is particularly interested in supervising projects that integrate multomics and translational approaches to tackle emerging challenges in public health and medical entomology.
Themes
- Innovation to Impact: Therapeutics, Diagnostics, Vaccines
- Malaria and Neglected Tropical Diseases
- Vector Control and Resistance Management
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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Multimodal platform for ITN efficacy: Surface chemistry, bioavailability, and mosquito behavior
Ismail, H. M., Tsing Tang, N., Jones, J., Walker, K., Thornton, J., Paine, M., Karl, S., Reimer, L. & Raval, R., 8 Apr 2026, In: Science advances. 12, 15, p. 1-14 14 p., eaeb2023.Research output: Contribution to journal › Article › peer-review
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Aedes aegypti control in breeding sites through an insecticidal coating with dual effect: Laboratory trials and safety assessment
Cárdenas, R., Cabrera, O. L., Carrillo, M. A., Pineda, A., Ahumada, M. L., Yañez, Y., Ismail, H. M., Paine, M., Rivera, T. & Kroeger, A., 1 Jun 2025, In: Medical and Veterinary Entomology. 39, 2, p. 252-265 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii
Muhammad, A., Ibrahim, S. S., Ismail, H. M., Irving, H., Paine, M. J. I. & Wondji, C. S., 7 Nov 2025, In: BMC Genomics. 26, 1, 1018.Research output: Contribution to journal › Article › peer-review
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Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae
Balaska, S., Grigoraki, L., Lycett, G., Weetman, D., Oladepo, F., Colman, F., Vontas, J., Paine, M. J. I. & Ismail, H. M., 28 Nov 2025, In: Nature Communications. 16, 1, 10772.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Significant variations in tolerance to clothianidin and pirimiphos-methyl in Anopheles gambiae and Anopheles funestus populations during a dramatic malaria resurgence despite sustained indoor residual spraying in Uganda
Oruni, A., Arinaitwe, E., Adiga, J., Otto, G., Kyagamba, P., Okoth, J., Ayo, D., Asiimwe, J. R., Zedi, M., Rek, J., Walker, K. J., Braithwaite, A., Kayondo, J., Conrad, M. D., Bousema, T., Paine, M. J. I., Ismail, H. M., Krezanoski, P., Wondji, C. S. & Kamya, M. R. & 2 others, , 23 Jun 2025, In: Parasites and Vectors. 18, 1, 237.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)