Research output per year
Research output per year
Personal profile
Biography
Eric Lucas received a BA in Natural Sciences (specialising in Zoology) from Cambridge in 2003 and obtained his PhD on the evolution of sociality in wasps from the University of Sussex in 2009. After this, he moved to the University of Lausanne for a PostDoc investigating the transcriptional basis of ageing and lifespan in ants. He joined Liverpool School of Tropical Medicine in 2016 to research the evolutionary genomics of insecticide resistance in mosquitoes.
Research interests
Eric’s work on insecticide resistance focuses on two main aspects. The first aims to understand the importance of copy number variants and its association with insecticide resistance. Genome-wide analysis has shown that copy number variants have played an important role in the evolution of resistance, with repeated independent mutations in the same set of genes driven to high frequencies by positive selection, and association between these copy number variants and resistance to several insecticides. The second aspect aims to detect new genes and mutations involved in insecticide resistance and to build predictive models of insecticide resistance using genetic and transcriptomic data.
Eric is part of the analysis team for the anopheles gambiae 1000 Genomes project and the Vector Observatory. He is also a member of the Genomics for African Anopheles Resistance Diagnostics network, which is applying whole genome sequencing to detect new resistance mutations and to embed genetic entomological monitoring into field trials of new mosquito control tools.
Teaching
Eric is a module convener for the Bioinformatics module from the Tropical Disease Biology MSc course. He also teaches introduction to R for MSc and MRes students.
Themes
- Malaria and Neglected Tropical Diseases
- Vector Control and Resistance Management
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Collaborations and top research areas from the last five years
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1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk
Crawford, J. E., Balcazar, D., Redmond, S., Rose, N. H., Youd, H., Lucas, E., Sudirman Made Ali, R., Alnazawi, A., Badolo, A., Chen, C. H., V. Cosme, L., A. Henke, J., Y. Hung, K., Kluh, S., Liu, W.-L., Maringer, K., Martins, A. J., Micieli1, M. V., Pless, E. & Sombié, A. & 8 others, , 18 Sept 2025, In: Science. 389, 6766, p. eads3732 13 p., eads3732.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Genomic diversity of the African malaria vector Anopheles funestus
Boddé, M., Nwezeobi, J., Korlević, P., Makunin, A., Akone-Ella, O., Barasa, S., Gadji, M., Hart, L., Kaindoa, E. W., Love, K., Lucas, E. R., Lujumba, I., Máquina, M., Nagi, S. C., Odero, J. O., Polo, B., Sangbakembi, C., Dadzie, S., Koekemoer, L. L. & Kwiatkowski, D. & 10 others, , 18 Sept 2025, In: Science (New York, N.Y.). 389, 6766, eadu3596.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
Copy number variants underlie major selective sweeps in insecticide resistance genes in Anopheles arabiensis
Lucas, E., Nagi, S., Kabula, B., Batengana, B., Kisinza, W., Egyir-Yawson, A., Essandoh, J., Dadzie, S., Chabi, J., Van’t Hof, A. E., Rippon, E., Pipini, D., Harding, N. J., Dyer, N., Clarkson, C. S., Miles, A., Weetman, D. & Donnelly, M., 5 Dec 2024, In: PLoS Biology. 22, 12, p. e3002898 e3002898.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus) -
Cryptic population structure and insecticide resistance in Anopheles gambiae from the southern Democratic Republic of Congo
Dennis, T., Pescod, P., Barasa, S., Cerdeira, L., Lucas, E., Clarkson, C. S., Miles, A., Asidi, A., Manzambi, E. Z., Metelo, E., Zanga, J., Nsalambi, S., Irish, S. R., Donnelly, M., Agossa, F., Weetman, D. & Tezzo, F. W., 18 Sept 2024, In: Scientific Reports. 14, 1, p. e21782 21782.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
LLIN Evaluation in Uganda Project (LLINEUP)–effects of a vector control trial on Plasmodium infection prevalence and genotypic markers of insecticide resistance in Anopheles vectors from 48 districts of Uganda
Lynd, A., Gonahasa, S., Staedke, S., Oruni, A., Maiteki-Sebuguzi, C., Hancock, P. A., Knight, E., Dorsey, G., Opigo, J., Yeka, A., Katureebe, A., Kyohere, M., Hemingway, J., Kamya, M. R., McDermott, D., Lucas, E. & Donnelly, M., 24 Jun 2024, In: Scientific Reports. 14, 1, p. e14488 14488.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)