Personal profile
Biography
Research interests
Dylan’s main research interests include understanding how HIV-1 establishes and maintains latent infection, and how biological insights into this could be leveraged to reverse latent infection in the interest of allowing host immune mechanisms to clear infected cells – a strategy commonly referred to as the ‘Shock and Kill’ HIV cure strategy. To study this, he employs a mixture of standard molecular biology techniques, flow cytometry, genomics, transcriptomics and, most recently, epigenomics.
Education/Academic qualification
Bachelor, Honours Degree in Molecular and Cell Biology
2019
Award Date: 30 Mar 2020
Bachelor, University of Cape Town
2016 → 2018
Award Date: 31 Mar 2019
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Research output
- 10 Article
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Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease
Friedrich, V. D., Pennitz, P., Wyler, E., Adler, J. M., Postmus, D., Müller, K., Teixeira Alves, L. G., Prigann, J., Pott, F., Vladimirova, D., Hoefler, T., Goekeri, C., Landthaler, M., Goffinet, C., Saliba, A. E., Scholz, M., Witzenrath, M., Trimpert, J., Kirsten, H. & Nouailles, G., 23 Sept 2024, In: eBioMedicine. 108, p. e105312 105312.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19
Peidli, S., Nouailles, G., Wyler, E., Adler, J. M., Kunder, S., Voß, A., Kazmierski, J., Pott, F., Pennitz, P., Postmus, D., Teixeira Alves, L. G., Goffinet, C., Gruber, A. D., Blüthgen, N., Witzenrath, M., Trimpert, J., Landthaler, M. & Praktiknjo, S. D., 10 Jun 2024, (E-pub ahead of print) In: Cell Reports. 43, 6, p. e114328 114328.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus) -
TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.
Qu, B., Miskey, C., Gömer, A., Kleinert, R. D. V., Ibanez, S. C., Eberle, R., Ebenig, A., Postmus, D., Nocke, M. K., Herrmann, M., Itotia, T. K., Herrmann, S. T., Heinen, N., Höck, S., Hastert, F. D., von Rhein, C., Schürmann, C., Li, X., van Zandbergen, G. & Widera, M. & 10 others, , 4 Jun 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 23, p. e2407437121 e2407437121.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus) -
90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection
Bosquillon de Jarcy, L., Akbil, B., Mhlekude, B., Leyens, J., Postmus, D., Harnisch, G., Jansen, J., Schmidt, M. L., Aigner, A., Pott, F., Chua, R. L., Krist, L., Gentile, R., Mühlemann, B., Jones, T. C., Niemeyer, D., Fricke, J., Keil, T., Pischon, T. & Janke, J. & 9 others, , 1 Nov 2023, In: Clinical and Experimental Medicine. 23, 7, p. 3689-3700 12 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
Mhlekude, B., Postmus, D., Stenzel, S., Weiner, J., Jansen, J., Zapatero-Belinchón, F. J., Olmer, R., Richter, A., Heinze, J., Heinemann, N., Mühlemann, B., Schroeder, S., Jones, T. C., Müller, M. A., Drosten, C., Pich, A., Thiel, V., Martin, U., Niemeyer, D. & Gerold, G. & 2 others, , 25 Sept 2023, In: PLoS Pathogens. 19, 9 September, p. e1011657 e1011657.Research output: Contribution to journal › Article › peer-review
Open AccessFile