Personal profile
Biography
Charlotte Rawcliffe is an experienced clinical research professional with more than 20 years expertise in the design, management, and delivery of complex clinical trials. As Head of the Global Health Trials Unit at the Liverpool School of Tropical Medicine (LSTM), she leads the strategic and operational direction of the unit, ensuring the successful delivery of high-impact global health research. Her work focuses on trial efficiency, regulatory compliance, and capacity building to support research that addresses pressing health challenges worldwide.
Before her current role, Charlotte was Head of Trial Management at the Liverpool Clinical Trials Centre and Deputy Operational Director at the Liverpool Cancer Trials Unit. She has extensive experience overseeing international multi-centre trials, particularly in oncology and infectious diseases, and has played a key role in trial methodology development and process optimisation.
Charlotte holds an MSc in Genetic Epidemiology and a BSc in Microbiology from the University of Sheffield, alongside postgraduate qualifications in health research and clinical research. Her work aligns with international regulatory standards, and she is passionate about ensuring high-quality, ethical research.
Beyond her role at LSTM, Charlotte contributes to research capacity strengthening initiatives, mentoring early-career researchers, and serves on committees focused on clinical trial standards and ethics, particularly in low-resource settings. She is committed to fostering collaborations across academia, industry, and global research networks to drive meaningful improvements in clinical trial delivery and impact.
Research interests
Charlotte's research focuses on the operational delivery of clinical trials in global health, with a strong emphasis on capacity building and sustainable research infrastructure. The Global Health Trials Unit at LSTM is committed to improving trial efficiency, strengthening research governance, and ensuring high-quality, ethical research in diverse settings.
Charlotte is particularly interested in strategies that enhance operational efficiency, including digital trial management systems, innovative monitoring approaches, and adaptive trial designs that respond to real-world challenges.
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Collaborations and top research areas from the last five years
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Research output
- 12 Article
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Pancreatic Adenocarcinoma: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial
Palmer, D. H., Jackson, R., Springfeld, C., Ghaneh, P., Rawcliffe, C., Halloran, C. M., Faluyi, O., Cunningham, D., Wadsley, J., Darby, S., Meyer, T., Gillmore, R., Lind, P., Glimelius, B., Falk, S., Ma, Y. T., Middleton, G. W., Cummins, S., Ross, P. J. & Wasan, H. & 13 others, , 1 Apr 2025, In: Journal of Clinical Oncology. 43, 10, p. 1240-1253 14 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma
Sacco, J. J., Jackson, R., Corrie, P., Danson, S., Evans, T. R. J., Ochsenreither, S., Kumar, S., Goodman, A., Larkin, J., Karydis, I., Steven, N., Lorigan, P., Plummer, R., Patel, P., Psarelli, E., Olsson-Brown, A., Shaw, H., Leyvraz, S., Handley, L. & Rawcliffe, C. & 1 others, , 1 May 2024, In: European Journal of Cancer. 202, 114009.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial: a four-arm, multicentre, randomised, phase 2 trial
Ghaneh, P., Palmer, D., Cicconi, S., Jackson, R., Halloran, C. M., Rawcliffe, C., Sripadam, R., Mukherjee, S., Soonawalla, Z., Wadsley, J., Al-Mukhtar, A., Dickson, E., Graham, J., Jiao, L., Wasan, H. S., Tait, I. S., Prachalias, A., Ross, P., Valle, J. W. & O'Reilly, D. A. & 15 others, , 1 Feb 2023, In: The Lancet Gastroenterology and Hepatology. 8, 2, p. 157-168 12 p.Research output: Contribution to journal › Article › peer-review
Open Access251 Citations (Scopus) -
The Impact of Positive Resection Margins on Survival and Recurrence following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma
Ghaneh, P., Kleeff, J., Halloran, C. M., Raraty, M., Jackson, R., Melling, J., Jones, O., Palmer, D. H., Cox, T. F., Smith, C. J., O'Reilly, D. A., Izbicki, J. R., Scarfe, A. G., Valle, J. W., McDonald, A. C., Carter, R., Tebbutt, N. C., Goldstein, D., Padbury, R. & Shannon, J. & 12 others, , 1 Mar 2019, In: Annals of Surgery. 269, 3, p. 520-529 10 p.Research output: Contribution to journal › Article › peer-review
Open Access215 Citations (Scopus) -
What are the main inefficiencies in trial conduct: A survey of UKCRC registered clinical trials units in the UK: A survey of UKCRC registered clinical trials units in the UK
Duley, L., Gillman, A., Duggan, M., Belson, S., Knox, J., McDonald, A., Rawcliffe, C., Simon, J., Sprosen, T., Watson, J. & Wood, W., 8 Jan 2018, In: Trials. 19, 1, 15.Research output: Contribution to journal › Article › peer-review
Open Access41 Citations (Scopus)