Personal profile
Research interests
I'm investigating the use of small molecule inhibitors as potential therapies for treating snakebite, in particular the repurposing of compounds that have stalled at points along the therapeutic development pipeline. I am focused on in vitro assays to identify promising lead compounds, which are then passed through several developmental pipelines to improve their efficacy or druggability.
Education/Academic qualification
Bachelor, Biomedical Science (Hons), University of Surrey
1 Sept 2009 → 1 Jul 2013
Award Date: 1 Jul 2013
Themes
- Innovation to Impact: Therapeutics, Diagnostics, Vaccines
- Malaria and Neglected Tropical Diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults.
Abouyannis, M., Nyambura, Y. K., Ngome, S., Riako, D., Musyoki, J., Muiruri, C., Orindi, B., Else, L., Amara, A., Dickinson, L., Clare, R., Albulescu, L.-O., Westhorpe, A., Kool, J., Adetifa, I., Ndungu, F. M., FitzGerald, R., Khoo, S., Lalloo, D. & Casewell, N. & 1 others, , 27 Feb 2025, In: eBioMedicine. 113, p. e105600 105600.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus) -
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform
Albulescu, L.-O., Westhorpe, A., Clare, R., Woodley, C. M., James, N., Kool, J., Berry, N. G., O’Neill, P. M. & Casewell, N., 11 Jan 2024, In: Frontiers in Pharmacology. 14, p. 1331224 1331224.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus) -
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
Clare, R., Dawson, C., Westhorpe, A., Albulescu, L.-O., Woodley, C. M., Mosallam, N., Chong, D. J. W., Kool, J., Berry, N. G., O’Neill, P. M. & Casewell, N., 11 Jan 2024, In: Frontiers in Pharmacology. 14, p. 1328950 1328950.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus) -
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms
Hall, S. R., Rasmussen, S. A., Crittenden, E., Dawson, C., Bartlett, K., Westhorpe, A., Albulescu, L.-O., Kool, J., Gutiérrez, J. M. & Casewell, N., 14 Dec 2023, In: Nature Communications. 14, 1, p. e7812 7812.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus) -
Drug combination therapies effectively inhibit the dermonecrotic activity of cytotoxic venoms from geographically diverse snake species in vivo
Hall, S., Crittenden, E., Dawson, C., Bartlett, K., Westhorpe, A., Albulescu, L.-O. & Casewell, N., 11 Jan 2023, In: British Journal of Pharmacology. 180, 4, p. 540-541 1 p.Research output: Contribution to journal › Meeting Abstract
Open AccessFile